个人简介

孔德坤，男，博士。2016年于上海交通大学微生物代谢国家重点实验室获微生物学博士学位。2017年-2019年，于博雅生物制药集团股份有限公司从事博士后研究工作。2019年至今供职于西南大学生物技术中心。主要研究方向1. 链霉菌和真菌来源的生物活性天然产物的发现和结构鉴定；2. 天然产物的生物合成与组合生物学；3. 酶催化反应的机理和应用

    联系方式  

    邮箱: kongdekun@swu.edu.cn  

    通讯地址：重庆市北碚区天生路2号西南大学 农业科学研究院（隆平楼）405

    发表论文和专利  

    1. Kong Dekun; Wang Xia; Nie Ju; Niu Guoqing*; Regulation of antibiotic production by signaling molecules in Streptomyces, Frontiers in Microbiology, 2019, 10:2927.  

    2. Wang Xiaozheng^#; Kong Dekun^#; Huang Tingting; Deng Zixin; Lin Shuangjun*; StnK2 catalysing a Pictet–Spengler reaction involved in the biosynthesis of the antitumor reagent streptonigrin, Organic & Biomolecular Chemistry, 2018, 16: 9124-9128.  

    3. Kong Dekun; Zou Yi; Zhang Zhang; Xu Fei; Brock Nelson; Zhang Liping; Deng Zixin; Lin Shuangjun*; Identification of (2S,3S)-β-methyltryptophan as the real biosynthetic intermediate of antitumor agent streptonigrin, Scientific Reports, 2016, 6:20273.  

    4. Wo Jing; Kong Dekun; Brock Nelson; Xu Fei; Zhou Xiufen; Deng Zixin; Lin Shuangjun*; Transformation of streptonigrin to streptonigrone: Flavin reductase-mediated flavin-catalyzed concomitant oxidative decarboxylation of picolinic acid derivatives, ACS Catalysis, 2016, 6 (5): 2831-2835.

    5. Kong Dekun^#; Lee Mi-Jin^#; Lin Shuangjun*; Kim Eung-Soo*; Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes, Journal of Industrial Microbiology & Biotechnology, 2013, 40 (6): 529-543.   

    6. Fei Xu, Dekun Kong, Xinyi He, Zhang Zhang, Mo Han, Xinqiang Xie, Peng Wang, Hairong Cheng, Meifeng Tao, Liping Zhang, Zixin Deng, and Shuangjun Lin*. Characterization of Streptonigrin Biosynthesis Reveals a Cryptic Car boxy I Methylation and an Unusual Oxidative Cleavage of a N-C Bond[J]. Journal of the American Chemical Society, 2013, 135(5):1739-1748.                                     

    7. Yi Zou, Haixing Yin, Dekun Kong, Zixin Deng, and Shuangjun Lin*. A Trans‐Acting Ketoreductase in Biosynthesis of a Symmetric Polyketide Dimer SIA7248[J]. ChemBioChem, 2013, 14(6).                                           

    8. Yi Zou, Qi Fang, Haixing Yin, Zutao Liang, Dekun Kong, Linquan Bai, Zixin Deng, Shuangjun Lin*. Stereospecific Biosynthesis of β-Methyltryptophan fromL-Tryptophan Features a Stereochemical Switch[J]. Angewandte Chemie International Edition, 2013.

    9. Mi-Jin Lee^#; Dekun Kong^#; Kyuboem Han; David H. Sherman; Linquan Bai; Zixin Deng; Shuangjun Lin; Eung-Soo Kim*; Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in pseudonocardia autotrophica. Applied Microbiology and Biotechnology, 2012, 95(1), p.157-168.   

    10. 发明专利：含有缩宫素的药物组合物及其制备方法。  

    11. 发明专利：稳定的缩宫素药物组合物及其制备方法。