张觅
博士,副研究员,博士生导师。2011年6月毕业于西南大学,获作物遗传育种专业博士学位。2011年7月至今供职于西南大学生物技术中心,主要从事生长素与极性细胞发育方面的研究。重庆市杰出青年、重庆市青年拔尖人才、全国优秀博士学位论文、教育部 “新世纪优秀人才”获得者。2014年,赴加拿大麦吉尔大学博士后2年,研究内质网的形成与细胞极性调控关系。相关研究以一作在Nature Biotechnology, Nature communication,Journal of Experimental Botany, Plant and cell physiology等刊物上发表。
联系方式
电子邮箱:selenazm@swu.edu.cn
电话:13752915215
ORCID:0000-0001-8180-2029
通讯地址:重庆市北碚区天生路2号西南大学生物技术中心(南校区隆平楼508室)
研究兴趣
以纤维细胞为载体,研究生长素调控细胞极性发育机制,以及目标性状的遗传改良。当前研究兴趣为
l 生长素运输载体PIN的极性调控
l 生长素对极性细胞发育的调控机制
l 纤维细胞性状的遗传改良
主持课题
1. 重庆市自然科学基金:棉花纤维细胞中生长素运输载体GhPIN3a的调控蛋白鉴定及功能研究(40万),cstc2021ycjh-bgzxm0110,2021.6-2024.5
2. 重庆市英才项目青年拔尖专项资金(40万),CQYC2020057993,2021.1-2023.12
3. 西南大学基本科研业务费专项资金项目:棉花纤维细胞中削弱GhPIN3a蛋白质膜定位的调控基因研究(20万),项目编号:XDJK2020B040,2020.1-2022.12
4. 国家自然科学基金面上项目:棉花GhPIN3a调控纤维细胞中生长素积累的机理(60万),项目编号:31871676,2019.1-2022.12
5. 高等学校全国优秀博士学位论文作者专项资金:棉花中生长素运输蛋白GhPIN调控纤维起始机理研究(66万),项目编号201466,2014.1-2018.12
6. “新世纪优秀人才支持计划”专项资金(50万),NCET-13-0972, 2014.1-2016.12
7. 国家自然科学基金青年科学基金项目:生长素极性运输对棉花纤维起始细胞中IAA积累的调控研究(26万),项目编号:31201248,2013.1-2015.12
8. 重庆市杰出青年科学基金项目:棉花纤维起始细胞中生长素积累的分子机理研究(60万),项目编号:cstc2012jjjq80001,2012.7-2015.6
9. 西南大学基本科研业务费专项资金项目:生长素调控纤维细度的分子机理研究(10万),项目编号:XDJK2012B017,2012.1-2014.12
发表论文
1. Zhang L, Guo Y, Zhang Y, Li Y, Pei Y, Zhang M* (2023) Regulation of PIN-FORMED Protein Degradation. International Journal of Molecular Sciences 24: 843
2. Xi J, Zeng J, Fu X, Zhang L, Li G, Li B, Yan X, Chu Q, Xiao Y, Pei Y, Zhang M* (2023) GhROP6 GTPase modulates auxin accumulation in cotton fibers by regulating cell-specific GhPIN3a localization. J Exp Bot 74: 265-282
3. Zeng J, Xi J, Li B, Yan X, Dai Y, Wu Y, Xiao Y, Pei Y, Zhang M* (2022) Microtubules play a crucial role in regulating actin organization and cell initiation in cotton fibers. Plant Cell Rep 41(4):1059-1073
4. Li B, Zhang L, Xi J, Hou L, Fu X, Pei Y, Zhang M* (2022) An unexpected regulatory sequence from Rho-related GTPase6 confers fiber-specific expression in upland cotton. Int J Mol Sci 23(3):1087
5. Wang F, Li X, Li Y, Han J, Chen Y, Zeng J, Su M, Zhuo J, Ren H, Liu H, Hou L, Fan Y, Yan X, Song S, Zhao J, Jin D, Zhang M, Pei Y* (2021) Arabidopsis P4 ATPase-mediated cell detoxification confers resistance to Fusarium graminearum and Verticillium dahliae. Nat Commun 12: 6426
6. Chen Y, Zhang M, Wang L, Yu X, Li X, Jin D, Zeng J, Ren H, Wang F, Song S, Yan X, Zhao J, Pei Y* (2021) GhKWL1 Upregulates GhERF105 but Its Function Is Impaired by Binding with VdISC1, a Pathogenic Effector of Verticillium dahliae. Int J Mol Sci 22
7. Sun J#, Zhang M#, Qi X, Doyle C, Zheng H* (2020) Armadillo-repeat kinesin1 interacts with Arabidopsis atlastin RHD3 to move ER with plus-end of microtubules. Nat Commun 11: 5510 (#, equal contributors)
8. Zhang M, Cao H, Xi J, Zeng J, Huang J, Li B, Song S, Zhao J, Pei Y* (2020) Auxin Directly Upregulates GhRAC13 Expression to Promote the Onset of Secondary Cell Wall Deposition in Cotton Fibers. Front Plant Sci 11: 581983
9. Jianyan Zeng#, Mi Zhang#, Lei Hou, Wenqin Bai, Xingying Yan, Nan Hou, Hongxing Wang, Juan Huang, Juan Zhao and Yan Pei* (2019) Cytokinin inhibits cotton fiber initiation via disrupting PIN3a-mediated IAA asymmetric accumulation in ovule epidermis, Journal Of Experimental Botany 70:3139 (#, equal contributors)
10. Zhang M, Zeng J, Cao H, Pei Y* (2019) YC3.60-Based Imaging Analysis on Calcium Level in Cotton Cells. In B Zhang, ed, Transgenic Cotton: Methods and Protocols. Springer, New York, pp 177-185
11. Zhang M, Cao H, Hou L, Song S, Zeng J, Pei Y* (2017) In vivo imaging of Ca2+ accumulation during cotton fiber initiation using fluorescent indicator YC3.60. Plant Cell Reports 36: 911-918
12. Zhang M, Xiao Y, Zeng J, Pei Y* (2017) PIN-formed protein, a door to reveal the mechanism for auxin-triggered initiation of cotton fiber. Plant Signaling & Behavior 12: e1319031
13. Zhang M#, Zeng J#, Long H, Xiao Y, Yan X, Pei Y* (2017) Auxin regulates cotton fiber initiation via GhPIN-mediated auxin transport. Plant and Cell Physiology 58: 385-397 (#, equal contributors)
14. Zhao J, Bai W, Zeng Q, Song S, Zhang M, Li X, Hou L, Xiao Y, Luo M, Li D, Luo X, Pei Y* (2015) Moderately enhancing cytokinin level by down-regulation of GhCKX expression in cotton concurrently increases fiber and seed yield. Molecular Breeding 35: 1-11
15. Xiao Y, Yan Q, Ding H, Luo M, Hou L, Zhang M, Yao D, Liu H, Li X, Zhao J, Pei Y* (2014) Transcriptome and biochemical analyses revealed a detailed proanthocyanidin biosynthesis pathway in brown cotton fiber. PLoS One 9: e86344
16. Zeng Q-w, Qin S, Song S-q, Zhang M, Xiao Y-h, Luo M, Hou L, Pei Y* (2012) Molecular cloning and characterization of a cytokinin dehydrogenase gene from upland cotton (Gossypium hirsutum L.). Plant Molecular Biology Reporter 30: 1-9
17. Zhang M#, Zheng X#, Song S, Zeng Q, Hou L, Li D, Zhao J, Wei Y, Li X, Luo M, Xiao Y, Luo X, Zhang J, Xiang C, Pei Y* (2011) Spatiotemporal manipulation of auxin biosynthesis in cotton ovule epidermal cells enhances fiber yield and quality. Nature Biotechnology 29: 453-458 (#, equal contributors)
18. Xiao Y, Li D, Yin M, Li X, Zhang M, Wang Y, Dong J, Zhao J, Luo M, Luo X, Hou L, Hu L, Pei Y* (2010) Gibberellin 20-oxidase promotes initiation and elongation of cotton fibers by regulating gibberellin synthesis. Journal of Plant Physiology 167: 829-837
其它主要学术成果
1. 张觅,席敬,曾健晏,阎星颖,李保霞,赵娟,裴炎,GTP结合蛋白基因GhROP6在调控棉花纤维性状中的应用,2021.10.26,国家发明专利,ZL202010562774.9
2. 裴炎,张觅,罗明,肖月华,侯磊,植物激素生物合成相关基因在棉花纤维发育中的功能及应用, 重庆市自然科学一等奖, 2015.6.1
3. 张觅,裴炎,李德谋,宋水清,赵娟,李改玲,唐静,李先碧,表达生长素代谢基因iaaL的载体及其用途,2014.8.13,国家发明专利,ZL201410246979
4. 张觅, 在胚珠表皮中时空调控生长素的生物合成提高转基因棉花的纤维产量和品质,2013年全国优秀博士学位论文, 2014.3.14